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Main project
Why Amphibians can regenerate their appendages after traumatic injury???
Current finding
1. JunB functions as a essential positive regulator of cell proliferation in tissue regeneration.
2. The expression of junb is induced just after tail amputation by TGF-β signaling.
(Nakamura et al., Biochem. Biophys. Res. Commun. 2020)
Collaboration with National Xenopus Resource (NXR) in USA.
Supported by NXR, NBRP (AMED), KAKENHI....
Research in progress
1. How does JunB activate cell proliferation. There are several candidates, ROS synthesis, Inflammation, morphogen signals, reprogramming.....
2. How is the expression of regeneration-specific genes induced immediately just after amputation.
Collaboration with several biological area
With my colleges (Regeneration group & Embryogenesis, Disease model group)
1. What is a partner of JunB in Xenopus tail regeneration?
2. How does amphibians response injury to activate gene expression?
3. Do other JunB-related genes function in tissue regeneration?
4. How does clk2 contribute to autism spectrum disorder?
With National Xenopus Resource in USA
1. How does JunB activate cell proliferation using CRISPR-mediated KO tadpoles.
With other groups in Hiroshima University
1. Collaboration with Ide lab: in progress
2. Collaboration with Arakawa lab: in progress
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